Acetaldehyde-Mediated Neurotoxicity: Relevance to Fetal Alcohol Spectrum Disorders
نویسندگان
چکیده
منابع مشابه
Acetaldehyde-Mediated Neurotoxicity: Relevance to Fetal Alcohol Spectrum Disorders
Ethanol-induced neuro-developmental abnormalities are associated with impaired insulin and IGF signaling, and increased oxidative stress in CNS neurons. We examined the roles of ethanol and its principal toxic metabolite, acetaldehyde, as mediators of impaired insulin/IGF signaling and oxidative injury in immature cerebellar neurons. Cultures were exposed to 3.5mM acetaldehyde or 50mM ethanol ±...
متن کاملFetal Alcohol Spectrum Disorders.
Prenatal exposure to alcohol can damage the developing fetus and is the leading preventable cause of birth defects and intellectual and neurodevelopmental disabilities. In 1973, fetal alcohol syndrome was first described as a specific cluster of birth defects resulting from alcohol exposure in utero. Subsequently, research unequivocally revealed that prenatal alcohol exposure causes a broad ran...
متن کاملFetal Alcohol Spectrum Disorders
Forty years ago, alcohol was not commonly recognized as a teratogen, an agent that can disrupt the development of a fetus. Today, we understand that prenatal alcohol exposure induces a variety of adverse effects on physical, neurological, and behavioral development. Research supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) has contributed to the identification of the ...
متن کاملFetal alCoHol sPeCtruM disorders
Objective: To conduct a combined analysis of the estimated effects of maternal average weekly alcohol consumption, and any binge drinking, in early to mid pregnancy on general intelligence, attention, and executive function in 5-year-old children. Design: Follow-up study. Setting: Neuropsychological testing in four Danish cities 2003–2008. Population: A cohort of 1628 women and their children s...
متن کاملFetal Alcohol Spectrum Disorders (fasd)
Establishing a unique neurobehavioural profile for people exposed to alcohol in utero would be a tremendous aid in diagnosis, treatment planning and epidemiological research. Epidemiological studies of fetal alcohol syndrome have shown that only one?third of the babies born to mothers who drank heavily during pregnancy presented with full-blown FAS. 2 Moreover, the majority of people who were e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2011
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2011/213286